For peripheral blood collection, venous access will be established with a small gauge needle.
The discard method will be adopted for catheter lines collection. Each catheter line is washed with 20 ml of 0.
Using another syringe, the blood volume needed to perform the analysis will then be collected. Additionally, another blood sample will be collected from the catheter line not used to infuse the drug after the discard of 10 mL.
Description IRS2 belongs to the vhat receptor substrate IRS protein family, which is characterized by the presence of a pleckstrin homology Preto domain and a phosphotyrosine line Ribeirao domain Figure 1 in nude protein structure. The PH domain contributes to protein-protein binding and facilitates the recruitment of IRS proteins by cell membrane receptors. The PTB domain contains chat tyrosine sites for phosphorylation and is dirty chat groups by cell receptors.
Expression Figure 2. Note the predominant cytoplasm localization of IRS2.
Personal data. Localisation IRS2 protein is predominantly found in the cytoplasm Figure 2.
Function IRS2 is a kDa adapter protein described in as being equivalent to telephone chat bellevue 4PS protein ly identified as a substrate associated with the IL4 receptor in myeloid cells Patti, et al. IRS2 also activates aling pathways through other mechanisms non-canonical pathways. The main aling pathways stimulated by IRS2 are shown dibeirao Figure 3.